What is it?
Hyperadrenocorticism (more commonly known as Cushing’s disease) is an overproduction of cortisol hormone. At normal levels, cortisol helps in response to stress and regulate the immune system. Cushing’s disease is one of the most common endocrine diseases in dogs.
Some common symptoms include:
- Increased thirst
- Increased urination
- Increased hunger
- Increased panting
- Distended abdomen
- Loss of hair
- Muscle weakness and loss
- Darkening of skin
- Lack of energy
- Increased Urine Cortisol:Creatinine Ratios
Not all symptoms are present in every patient and some of these symptoms can also be seen with other diseases. Only your veterinarian can diagnose if your pet has Cushing’s.
There are multiple causes:
- Excessive administration of corticosteroid medications.
- Benign pituitary tumor (rarely can be malignant).
- Adrenal gland tumor (adrenal-dependent hyperadrenocorticism/ADH).
- Pituitary-dependent hyperadrenocorticism (PDH) – the body naturally produces too much hormone.
Your pet’s veterinarian will first take a detailed history and do a complete physical exam. Next step is to perform a full blood chemistry, complete blood count, and urinalysis. These diagnostics will help the veterinarian get a bigger picture of what is happening in the body. Further testing that can help diagnose specific causes include: urine cortisol/creatinine ratio then ACTH stimulation test or Dexamethasone suppression test. The stimulation and suppression tests help determine specifically how much cortisol is being produced and how best it should be treated.
- Excessive administration of corticosteroid medications: Treatment is to slowly wean off the medications according to your veterinarian’s instructions.
- Benign pituitary tumor and Adrenal gland tumor: First, a metastases check is performed to make sure the tumor has not spread to other organs. Then, a medication is given called trilostane (Vetoryl) to shrink the tumor. Once the tumor has decreased in size, it is removed.
- Pituitary-dependent hyperadrenocorticism: The pet is put on trilostane for life. This controls the production of cortisol.
Living with Cushing’s Disease
This is a serious disease, but it can be managed if pet owners and veterinarians work together. This is a lifelong diagnosis and does require medications to be given long term. Periodic monitoring will be required to make sure the treatment is going as it should and to help the veterinarians know if an adjustment needs to be made.
Common Diseases of Companion Animals By Alleice Summers
By: Jamie McAfee
We’ve all seen cats drinking in weird places. No, not your local dive bar – I’m talking the kitchen sink, the bathtub, that dripping faucet in the bathroom, or even the toilet.
Instinctively, our feline friends are hard wired to prefer running water over standing water simply because all of today’s domestic cats are descended from the same ancestor: the African wildcat. In the wild, standing water wasn’t as fresh and posed more risk of sickness than running water did. These practices passed on from generation to generation and are still seen today in our pets at home. Regardless of the reason why cats prefer running water, getting adequate water intake is important for your cat’s overall health, and to maintain a healthy urinary tract.
Cats are designed to get their necessary water from the prey they eat. Many pet guardians feed their cats dry food which has water content of about 10%, compared to approximately 70-80% in most canned food. Cats that eat a dry kibble diet rather than wet food will drink more water to compensate, but still run the risk of becoming dehydrated. Anything you can do to encourage your cat to drink more water will help. Cats that are only given standing water often drink far too little and this may result in disorders of the urinary tract, including bladder stones or chronic feline lower urinary tract disease (FLUTD) and as a result, any existing small urinary crystals aren’t completely flushed out and can develop into gravel and then larger stones (so-called struvite stones, for example).
In severe cases, a urinary stone can completely obstruct the urethra, which means that urine – and hence the body’s toxic wastes – can no longer be eliminated from the body and backs up into the kidneys. This blockage is life-threatening. An increased intake of water helps prevent urinary tract disease because the urine contains a lower concentration of the mineral substances that can cause these disorders. And a larger volume of urine makes the cat empty his or her bladder more frequently, which in turn means that the minerals responsible for forming urinary stones spend less time inside the body and the body’s own toxic substances are successfully eliminated in the urine.
A drinking fountain re-circulates and filters the water, making it fresher-tasting and encouraging your cat to drink more. It also adds movement which attracts the cat’s eye as well as an appeasing sound that entices them to investigate, play, and ultimately drink from them. Because the water in a drinking fountain goes through a charcoal filter to remove odors and impurities, it is healthier for your cat than stale water that has been standing and collecting debris. Also, a pet water fountain will provide the running water that your cat prefers without the wastefulness of leaving your tap running continuously.
by: Kaitie Barczak